Improved control over particle sizes and stability of concentrated fluorocarbon emulsions by using mixed fluorocarbon/hydrocarbon molecular dowels

Artif Cells Blood Substit Immobil Biotechnol. 1994;22(4):1183-91. doi: 10.3109/10731199409138814.

Abstract

The use of a surfactant system consisting in equimolar amounts of egg yolk phospholipids and of a mixed fluorocarbon/hydrocarbon amphiphile (C8H17CH = CHC8F17) allows the preparation of concentrated (90% w/v, i.e. 47% v/v) emulsions of perfluorooctyl bromide (perflubron), with average particle sizes ranging from 0.12 to 16 microns post-sterilization, depending on the surfactant/fluorocarbon ratio. Emulsion droplet diameters varied linearly as a function of the emulsifier's concentration, thus allowing easy pre-determination of the emulsion's average particle size. Excellent stability was observed for the dowel-containing emulsions for at least 6 months at 40 degrees C over the whole domain of particle sizes investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Stability
  • Emulsions
  • Fluorocarbons / chemistry*
  • Hydrocarbons, Brominated
  • Hydrocarbons, Fluorinated*
  • Linear Models
  • Molecular Weight
  • Particle Size
  • Surface-Active Agents

Substances

  • Emulsions
  • Fluorocarbons
  • Hydrocarbons, Brominated
  • Hydrocarbons, Fluorinated
  • Surface-Active Agents
  • 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-9-octadecene
  • perflubron