Objective: To show that intrauterine anesthesia is a reliable method for reducing pain associated with endocavitary procedures.
Design: A prospective, randomized, double-blind study.
Setting: The Department of Obstetrics and Gynecology, Tor Vergata University of Rome, Rome, Italy.
Patients: Forty-five patients undergoing diagnostic hysteroscopy (n = 27) or hysteroscopy and endometrial biopsy (n = 18).
Interventions: Five milliliters of 2% mepivacaine or saline solution were injected transcervically into the uterine cavity before performing the procedures.
Main outcome measures: Evaluation of pain reduction on a visual analogue scale.
Results: Pain expectation and pain reported were reduced during and after the procedures.
Conclusion: Topical anesthesia effectively reduces pain during hysteroscopy and endometrial biopsy.