[Critical review of theories on cell aging. From Hayflick's basis concept to the concept of critical threshold of accumulation of errors]

Pathol Biol (Paris). 1994 Apr;42(4):313-21.
[Article in French]

Abstract

The goal of this review of the theories of cellular ageing is first to distinguish the theories on the basis of logical criteria following the dichotomies genetic/environmental and deterministic/stochastic. The second purpose is to show, from such criteria, that these theories can be integrated in a more general concept, which is the concept of critical threshold of error accumulation, taking into account the protective role of defenses systems avoiding a quick increase in the level of intracellular errors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cellular Senescence / genetics
  • Cellular Senescence / physiology*
  • Humans