Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity

E Alcalde; L Pérez-García; I Dinarés; J Frigola

doi:10.1248/cpb.43.493

Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity

Chem Pharm Bull (Tokyo). 1995 Mar;43(3):493-8. doi: 10.1248/cpb.43.493.

Authors

E Alcalde¹, L Pérez-García, I Dinarés, J Frigola

Affiliation

¹ Laboratorio de Química Orgánica, Facultad de Farmacia, Universidad de Barcelona, Spain.

PMID: 7774033
DOI: 10.1248/cpb.43.493

Abstract

The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antitrichomonal Agents / chemical synthesis*
Antitrichomonal Agents / chemistry
Antitrichomonal Agents / pharmacology*
Benzimidazoles / chemical synthesis*
Benzimidazoles / chemistry
Benzimidazoles / pharmacology*
Betaine / analogs & derivatives*
Betaine / chemistry
Betaine / pharmacology*
Lethal Dose 50
Microbial Sensitivity Tests
Structure-Activity Relationship
Trichomonas vaginalis / drug effects

Substances

Antitrichomonal Agents
Benzimidazoles
Betaine