Abstract
During our screening program for natural product drugs effective against multidrug-resistant mammalian cells, we have discovered a new delta lactone FD-211 from the fermantation broth of Myceliophthora lutea TF-0409. FD-211 had a broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Leukemia P388 / drug therapy
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Mice
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Microscopy, Electron, Scanning
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Mitosporic Fungi / metabolism
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Mitosporic Fungi / ultrastructure
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Spectrum Analysis
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Tumor Cells, Cultured
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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FD 211
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Lactones