A novel bioactive delta lactone FD-211. Taxonomy, isolation and characterization

J Antibiot (Tokyo). 1995 Feb;48(2):113-8. doi: 10.7164/antibiotics.48.113.

Abstract

During our screening program for natural product drugs effective against multidrug-resistant mammalian cells, we have discovered a new delta lactone FD-211 from the fermantation broth of Myceliophthora lutea TF-0409. FD-211 had a broad spectrum activity against cultured tumor cell lines, including adriamycin-resistant HL-60 cells.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology*
  • Leukemia P388 / drug therapy
  • Mice
  • Microscopy, Electron, Scanning
  • Mitosporic Fungi / metabolism
  • Mitosporic Fungi / ultrastructure
  • Spectrum Analysis
  • Tumor Cells, Cultured

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • FD 211
  • Lactones