A diterpene from Mikania obtusata active on Trypanosoma cruzi

Planta Med. 1995 Feb;61(1):85-7. doi: 10.1055/s-2006-958011.

Abstract

The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diterpenes / pharmacology*
  • Mice
  • Plants / chemistry*
  • Trypanocidal Agents / pharmacology*
  • Trypanosoma cruzi / drug effects*

Substances

  • Diterpenes
  • Trypanocidal Agents