Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica

Planta Med. 1995 Feb;61(1):41-4. doi: 10.1055/s-2006-957996.

Abstract

The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations. (+)-alpha-Viniferin inhibited keratinocyte proliferation (0.4 microM) and free radical release in whole blood (47 microM), in vitro, and may be useful in treating hyperproliferative or inflammatory skin diseases.

MeSH terms

  • Cells, Cultured
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Protein Kinase C / antagonists & inhibitors*
  • Stilbenes / isolation & purification
  • Stilbenes / pharmacology*

Substances

  • Drugs, Chinese Herbal
  • Stilbenes
  • Protein Kinase C