Hepatoid carcinoma of the stomach

Cancer. 1993 Jan 15;71(2):293-6. doi: 10.1002/1097-0142(19930115)71:2<293::aid-cncr2820710204>3.0.co;2-o.

Abstract

A patient with primary gastric carcinoma exhibiting hepatoid differentiation is described. The tumor itself was not associated with a high serum alpha-fetoprotein, but the cells stained positive for alpha-fetoprotein and alpha-1 antitrypsin. The patient underwent a total gastrectomy and wedge excision of the liver metastasis. The presence of metastatic hepatoid adenocarcinoma of the stomach should be considered in a patient who, during surgery for a primary gastric carcinoma, is found to have a liver metastasis that is diagnosed by frozen-section biopsy as a hepatoma. Because of lymph node and liver metastasis, prognosis appears to be poor for such patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma / pathology*
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / secondary
  • Humans
  • Liver Neoplasms / secondary*
  • Male
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Stomach Neoplasms / pathology*
  • alpha-Fetoproteins / analysis

Substances

  • alpha-Fetoproteins