A new device, the ThAIRapy Bronchial Drainage System, enables patients with cystic fibrosis to self-administer the technique of high frequency chest compression (HFCC) to assist with mucociliary clearance. We review the literature on HFCC and outline a case study of a patient currently using the ThAIRapy Bronchial Drainage System. While mucociliary clearance and lung function may be enhanced by HFCC therapy, more research is needed to determine its efficacy, cost benefits, and optimum treatment guidelines. Although our initial experience with the patient using this device has been positive, we were unable to accurately evaluate the ThAIRapy Bronchial Drainage System.