Abstract
Bacteria impose regulatory mechanisms on metabolic processes to ensure that the needs of the cell are met but not exceeded. Here, we discuss the basic features of a mechanism by which carbohydrate catabolism in Gram-positive bacteria is regulated. Although the physiological consequences of this regulation are the same as in Gram-negative bacteria, the mechanism is entirely different. These regulatory processes evidently evolved late, after the divergence of Gram-negative bacteria, even though the targets of regulation are universal.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bacterial Proteins / metabolism*
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Carbohydrate Metabolism*
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Escherichia coli Proteins*
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Gram-Negative Bacteria / metabolism*
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Gram-Positive Bacteria / metabolism*
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Membrane Transport Proteins / metabolism
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Monosaccharide Transport Proteins*
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Phosphoenolpyruvate Sugar Phosphotransferase System / metabolism
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Phosphorylation
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Signal Transduction / physiology
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Symporters*
Substances
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Bacterial Proteins
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Escherichia coli Proteins
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LacY protein, E coli
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Membrane Transport Proteins
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Monosaccharide Transport Proteins
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Symporters
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lactose permease
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Phosphoenolpyruvate Sugar Phosphotransferase System