Screening for in vitro anti-tumor promoting activities of edible plants from Thailand

Cancer Lett. 1995 Aug 16;95(1-2):139-46. doi: 10.1016/0304-3835(95)03879-2.

Abstract

A total of 112 species of edible plants (122 samples) from Thailand were randomly collected, and their methanol extracts were screened for in vitro anti-tumor promoting activity using the inhibition test of Epstein-Barr virus (EBV) activation in Raji cells induced by 12-O-hexadecanoylphorbol-13-acetate (HPA, 40 ng/ml). It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml. Significantly, the ratio is markedly higher than that (26%) previously observed in common edible plants in Japan. Thus, physiological potentiality of edible Thai plants has been implied in terms of cancer chemoprevention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / chemistry*
  • Herpesvirus 4, Human
  • Humans
  • In Vitro Techniques
  • Mutagenicity Tests
  • Plants, Edible / chemistry*
  • Plants, Medicinal / chemistry*
  • Thailand
  • Virus Replication / drug effects

Substances

  • Anticarcinogenic Agents