Abstract
n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Air Pollutants, Occupational / adverse effects*
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Blood Glucose / metabolism
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Brain / diagnostic imaging
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Brain / drug effects*
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Brain Mapping
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Corpus Striatum / diagnostic imaging
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Corpus Striatum / drug effects
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Hexanes / adverse effects*
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Humans
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Lipid Peroxidation / drug effects
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Lipid Peroxidation / physiology
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Male
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Middle Aged
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Neurologic Examination / drug effects
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Occupational Diseases / chemically induced*
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Occupational Diseases / diagnostic imaging
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Parkinson Disease, Secondary / chemically induced*
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Parkinson Disease, Secondary / diagnostic imaging
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Receptors, Dopamine / drug effects
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Receptors, Dopamine / physiology
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Substantia Nigra / diagnostic imaging
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Substantia Nigra / drug effects
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Tanning
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Tomography, Emission-Computed*
Substances
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Air Pollutants, Occupational
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Blood Glucose
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Hexanes
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Receptors, Dopamine
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n-hexane