Three more cyclotheonamides, C, D, and E, potent thrombin inhibitors from the marine sponge Theonella swinhoei

Bioorg Med Chem. 1995 Aug;3(8):1115-22. doi: 10.1016/0968-0896(95)00106-q.

Abstract

Three new thrombin and trypsin inhibitors, cyclotheonamides C (3), D (4), and E (8) were isolated from the marine sponge Theonella swinhoei. Their structures were determined by spectral and chemical methods.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antithrombins / chemistry*
  • Antithrombins / isolation & purification*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / isolation & purification
  • Porifera*
  • Serine Proteinase Inhibitors / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Structure-Activity Relationship
  • Thrombin / antagonists & inhibitors*
  • Trypsin Inhibitors / chemistry
  • Trypsin Inhibitors / isolation & purification*

Substances

  • Antithrombins
  • Peptides, Cyclic
  • Serine Proteinase Inhibitors
  • Trypsin Inhibitors
  • cyclotheonamide C
  • cyclotheonamide D
  • cyclotheonamide E
  • Thrombin