Abstract
Three new thrombin and trypsin inhibitors, cyclotheonamides C (3), D (4), and E (8) were isolated from the marine sponge Theonella swinhoei. Their structures were determined by spectral and chemical methods.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antithrombins / chemistry*
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Antithrombins / isolation & purification*
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / isolation & purification
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Porifera*
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Serine Proteinase Inhibitors / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Structure-Activity Relationship
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Thrombin / antagonists & inhibitors*
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Trypsin Inhibitors / chemistry
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Trypsin Inhibitors / isolation & purification*
Substances
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Antithrombins
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Peptides, Cyclic
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Serine Proteinase Inhibitors
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Trypsin Inhibitors
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cyclotheonamide C
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cyclotheonamide D
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cyclotheonamide E
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Thrombin