Abstract
A thiophene analogue 8 of the antifungal drug amorolfine (1) was prepared starting from the alcohol 5. In addition, congeners of naftifine, terbinafine and butenafine, in which the naphthalene ring is replaced by a branched thienylalkyl group, wee synthesized. Of the four drug analogues only compound 9, related to terbinafine, showed significant antifungal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemical synthesis*
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Amines / pharmacology
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Fungi / drug effects*
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Microbial Sensitivity Tests
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Morpholines / chemical synthesis*
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Morpholines / pharmacology
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Thiophenes / chemical synthesis*
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Thiophenes / pharmacology
Substances
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Amines
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Antifungal Agents
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Morpholines
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Thiophenes