Thiophene congeners of morpholine and allylamine type antifungals--syntheses and biological activities

Pharmazie. 1995 Aug;50(8):525-7.

Abstract

A thiophene analogue 8 of the antifungal drug amorolfine (1) was prepared starting from the alcohol 5. In addition, congeners of naftifine, terbinafine and butenafine, in which the naphthalene ring is replaced by a branched thienylalkyl group, wee synthesized. Of the four drug analogues only compound 9, related to terbinafine, showed significant antifungal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemical synthesis*
  • Amines / pharmacology
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology
  • Fungi / drug effects*
  • Microbial Sensitivity Tests
  • Morpholines / chemical synthesis*
  • Morpholines / pharmacology
  • Thiophenes / chemical synthesis*
  • Thiophenes / pharmacology

Substances

  • Amines
  • Antifungal Agents
  • Morpholines
  • Thiophenes