Use of robust statistical methods to determine the effect of fragile X on means and variance components of a quantitative trait

Genet Epidemiol. 1995;12(3):279-90. doi: 10.1002/gepi.1370120305.

Abstract

Owing to the presence of outliers, an estimated 3.5% in the ridge breadth data and 1.7% in the height data, the effect of fragile X on height and ridge breadth was examined using robust statistical techniques for data collected from 54 families afflicted with this disorder. It is shown that fragile X affects ridge breadth and height in a different manner. Fragile X women had a greater mean ridge breadth than normal women, whereas there was a similar trend, but no significant difference, between normal and fragile X men. Fragile X men were shorter than normal men, but no significant difference between the mean height of normal and fragile X women was observed. However, fragile X girls were shown to grow more quickly and to stop growing earlier than normal girls. An examination of the covariance between relatives classified according to fragile X status showed that for both traits the effect of fragile X was to reduce the covariance between parents and offspring, which produced the effect of departure from an additive polygenic model of inheritance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Analysis of Variance
  • Body Height
  • Child
  • Child, Preschool
  • Dermatoglyphics
  • Female
  • Fragile X Syndrome / epidemiology*
  • Fragile X Syndrome / genetics
  • Hand
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic*
  • Models, Statistical*
  • Normal Distribution
  • Pedigree
  • Phenotype
  • Regression Analysis
  • Sex Factors