Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus

Hum Gene Ther. 1995 Feb;6(2):205-18. doi: 10.1089/hum.1995.6.2-205.

Authors

M J Welsh¹, J Zabner, S M Graham, A E Smith, R Moscicki, S Wadsworth

Affiliation

¹ Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.

PMID: 7537540
DOI: 10.1089/hum.1995.6.2-205

No abstract available

MeSH terms

Adenoviruses, Human / genetics*
Clinical Protocols
Clinical Trials as Topic*
Cystic Fibrosis / therapy*
Cystic Fibrosis Transmembrane Conductance Regulator
Female
Gene Transfer Techniques* / adverse effects
Genetic Therapy* / adverse effects
Genetic Vectors / genetics
Humans
Male
Maxillary Sinus
Membrane Proteins / administration & dosage
Membrane Proteins / genetics*
Membrane Proteins / therapeutic use
Nasal Mucosa

Substances

CFTR protein, human
Membrane Proteins
Cystic Fibrosis Transmembrane Conductance Regulator