Comparison of nimesulide and diclofenac in the prevention and treatment of painful inflammatory postoperative complications of general surgery

Drugs. 1993:46 Suppl 1:159-61. doi: 10.2165/00003495-199300461-00038.

Abstract

In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resolution of mild fever. No adverse reactions attributable to treatment were observed.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Diclofenac / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Inflammation / drug therapy*
  • Male
  • Middle Aged
  • Pain, Postoperative / drug therapy*
  • Sulfonamides / therapeutic use*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Sulfonamides
  • Diclofenac
  • nimesulide