Abstract
Dolomite, a mineral composed of magnesium and calcium carbonates, potentiates the antitumoral activity of bleomycin: While 40 days after inoculation, no mice survived the Ehrlich ascites tumor burden, 44% of them survived it after bleomycin treatment, and 63% after a simultaneous treatment of bleomycin and dolomite. The beneficial antitumor effect of dolomite is probably related to its high content (12.8%) of magnesium.
MeSH terms
-
Animals
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Bleomycin / administration & dosage
-
Bleomycin / therapeutic use*
-
Calcium Carbonate / administration & dosage
-
Calcium Carbonate / therapeutic use*
-
Carcinoma, Ehrlich Tumor / drug therapy*
-
Female
-
Magnesium / administration & dosage
-
Magnesium / therapeutic use*
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Minerals / therapeutic use
Substances
-
Minerals
-
Bleomycin
-
Calcium Carbonate
-
Magnesium
-
calcium magnesium carbonate