Antitumoral effect of bleomycin+dolomite combination treatment, in mice bearing Ehrlich ascites carcinoma

Z Naturforsch C J Biosci. 1993 Sep-Oct;48(9-10):818-20. doi: 10.1515/znc-1993-9-1023.

Abstract

Dolomite, a mineral composed of magnesium and calcium carbonates, potentiates the antitumoral activity of bleomycin: While 40 days after inoculation, no mice survived the Ehrlich ascites tumor burden, 44% of them survived it after bleomycin treatment, and 63% after a simultaneous treatment of bleomycin and dolomite. The beneficial antitumor effect of dolomite is probably related to its high content (12.8%) of magnesium.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Bleomycin / therapeutic use*
  • Calcium Carbonate / administration & dosage
  • Calcium Carbonate / therapeutic use*
  • Carcinoma, Ehrlich Tumor / drug therapy*
  • Female
  • Magnesium / administration & dosage
  • Magnesium / therapeutic use*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Minerals / therapeutic use

Substances

  • Minerals
  • Bleomycin
  • Calcium Carbonate
  • Magnesium
  • calcium magnesium carbonate