Adjuvant effect of polyadenylic.polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

S J Park; W H Kim; K H Han; C Y Chon; K B Hahm; Y M Moon; J K Kang; I S Park; J K Youn

doi:10.1016/0192-0561(95)00031-v

Adjuvant effect of polyadenylic.polyuridylic acid on antibody production of recombinant hepatitis B surface antigen in mice

Int J Immunopharmacol. 1995 Jun;17(6):513-6. doi: 10.1016/0192-0561(95)00031-v.

Authors

S J Park¹, W H Kim, K H Han, C Y Chon, K B Hahm, Y M Moon, J K Kang, I S Park, J K Youn

Affiliation

¹ Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

PMID: 7499028
DOI: 10.1016/0192-0561(95)00031-v

Abstract

The adjuvant effect of polyadenylic.polyuridylic acid [poly(A).poly(U)] on antibody production against recombinant hepatitis B surface antigen (rHBsAg) was investigated. Immunization of adult Balb/c mice with rHBsAg plus poly(A).poly(U) elicited significantly higher antibody responses than immunization of mice immunized with rHBsAg alone. Such an adjuvant effect was evident even in mice sensitized with subimmunogenic doses of the antigen.

MeSH terms

Adjuvants, Immunologic / therapeutic use*
Animals
Antibodies, Viral / biosynthesis*
Antibodies, Viral / drug effects
Female
Hepatitis B / prevention & control*
Hepatitis B Surface Antigens / immunology*
Mice
Mice, Inbred BALB C
Poly A-U / therapeutic use*
Vaccines, Synthetic / immunology*
Vaccines, Synthetic / therapeutic use

Substances

Adjuvants, Immunologic
Antibodies, Viral
Hepatitis B Surface Antigens
Vaccines, Synthetic
Poly A-U