Pyrido[2,1-b]quinazolinecarboxylic acids as orally active antiallergy agents

J Med Chem. 1980 Jan;23(1):92-5. doi: 10.1021/jm00175a020.

Abstract

A series of 8-substituted pyrido[2,1-]quinazoline-2-carboxylic acids was prepared by the nickel carbonyl mediated carboxylation of the corresponding bromides. The activities of these compounds in the rat PCA test are comparable to those of the corresponding 2-substituted pyrido[2,1-b]quinazoline-8-carboxylic acids.

MeSH terms

  • Administration, Oral
  • Animals
  • Hypersensitivity / drug therapy*
  • Male
  • Passive Cutaneous Anaphylaxis / drug effects
  • Quinazolines / administration & dosage
  • Quinazolines / chemical synthesis*
  • Quinazolines / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Quinazolines