Amnion stored in a LIPK-s solution is recommended for airtight closure of a defect in the dura mater in infants and young children. It may also be used in adults. Animal experiments showed that the edges of the graft placed with the inner (fetal) surface on the brain grow tightly into the dura mater along the margins of the defect with no inflammatory changes or any coarse cicatrization even in injury to the cortex. Plastic surgery of the dura mater with the amnion was carried out in the clinic in 16 children from 4 months to 7 years of age with severe and moderately severe craniocerebral trauma. No complications developed after the operation. The follow-up period is more than 5 years.