[Experimental study of the "'rebound syndrome" following discontinuation of prolonged phenazepam administration and possibilities for preventing it]

Abstract

Phenazepam given to rats in a daily dose of 2 mg/kg intraperitoneally for a long (30 days) time ceased to produce the sedative effect, and discontinuation of the medication led to development of the so-called "recoil syndrome" characterized by general depression and disturbances of the conditioned-reflex activity. The "recoil syndrome" was distinguished for a selective specificity, since its motor and sensor manifestations were eliminated only by benzodiazepine derivatives (phenazepam, diazepam). Drugs from other chemical slasses (meprobamate, trioxazine, amipazin) did not influence this syndrome.