This monograph has considered the clinical features, differential diagnosis, diagnostic approaches, treatment and prognosis for primary and secondary tumors of the uveal tract. Tumors metastatic to the uvea are the most common intraocular malignant lesions, although primary uveal melanomas are recognized more frequently clinically. These tumors differ considerably with regard to clinical features and in the recommended approach to systemic evaluation and treatment. The diagnosis and management of such tumors should be a joint effort between the ophthalmologist and other physicians.