HLA antigen associations in hypertrophic cardiomyopathy

Tissue Antigens. 1982 Nov;20(5):389-93. doi: 10.1111/j.1399-0039.1982.tb02255.x.

Abstract

Histocompatibility antigen testing has been carried out in 20 unrelated normotensive English Caucasoids with hypertrophic cardiomyopathy and in 17 relatives, six of whom also had the disease. A strong association with the HLA-DRw6 antigen complex was found (P = 0.0036) but it was no longer significant after correction for the 52 antigens tested (P = 0.1701).

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cardiomyopathy, Hypertrophic / epidemiology
  • Cardiomyopathy, Hypertrophic / genetics
  • Cardiomyopathy, Hypertrophic / immunology*
  • Female
  • Genes, MHC Class II
  • HLA Antigens / genetics*
  • HLA Antigens / immunology
  • HLA-C Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • London
  • Male
  • Middle Aged

Substances

  • HLA Antigens
  • HLA-C Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II