Abstract
Thiourea, and .OH scavenger, reduced the gamma-radiation-induced changes in the rigidity of erythrocyte membrane lipids, the state of membrane proteins, and lipid peroxidation. Several .OH scavengers, but not superoxide dismutase, also inhibited the radiation-induced acceleration of the transport of a hydrophilic non-electrolyte spin label TEMPOL across the erythrocyte membrane. The effects of scavengers were usually biphasic with a maximum of the protective effect. Higher concentrations of the scavengers were less effective, as in the case of radioprotection of erythrocytes to haemolysis studied previously.
MeSH terms
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Animals
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Cattle
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Cobalt Radioisotopes
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Dose-Response Relationship, Drug
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Erythrocyte Membrane / drug effects
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Erythrocyte Membrane / radiation effects*
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Erythrocytes / radiation effects*
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Ethanol / pharmacology
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Formates / pharmacology
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Gamma Rays
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In Vitro Techniques
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Lipid Peroxides / metabolism
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Membrane Lipids / radiation effects
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Membrane Proteins / radiation effects
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Protein Conformation / drug effects
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Protein Conformation / radiation effects
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Radiation-Protective Agents / pharmacology*
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Spin Labels
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Superoxide Dismutase / pharmacology
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Thiourea / pharmacology
Substances
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Cobalt Radioisotopes
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Formates
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Lipid Peroxides
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Membrane Lipids
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Membrane Proteins
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Radiation-Protective Agents
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Spin Labels
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Ethanol
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Superoxide Dismutase
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Thiourea