[Cardiomyopathy with hepatic necrosis after several years of using Norbiogest Spofa]

Bratisl Lek Listy. 1983 Nov;80(5):603-9.
[Article in Slovak]

Abstract

PIP: Findings in a 28 year old woman who had been using the hormonal contraceptive Norbiogest Spofa for 3 years are described. She ceased taking the pill 40 days prior to her death. Congestive cardiomyopathy, massive hepatic necrosis, and hemorrhagic infarctions in the lungs and spleen were diagnosed at autopsy. The disease probably occurred in connection with previous pregnancies and had been gradually deteriorating her condition during drug application. Findings in the liver, lung, and spleen are considered a consequence of chronic heart insufficiency, even when the effect of the drug on venostatically changed organs could not be excluded. (author's modified)

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cardiomyopathy, Dilated / chemically induced*
  • Chemical and Drug Induced Liver Injury*
  • Contraceptives, Oral / adverse effects*
  • Contraceptives, Oral, Combined / adverse effects*
  • Female
  • Heart Failure / chemically induced*
  • Humans
  • Liver / pathology
  • Mestranol / adverse effects*
  • Necrosis
  • Norethindrone / adverse effects
  • Norethindrone / analogs & derivatives*

Substances

  • Contraceptives, Oral
  • Contraceptives, Oral, Combined
  • norbiogest
  • Mestranol
  • Norethindrone