In three cases of intraocular silicone oil injection in which the histologic picture is observed at different time intervals, emphasis is given to the fact that fibrous tissue formation around silicone vesicles is a rather constant complication and of early occurrence. Thus, we believe that the removal of liquid silicone from the eye should not take place later than two or three months after the injection. In our first reported case, there was an association of silicone oil injection and vitrectomy with retinal detachment procedures and sympathetic ophthalmia. In the absence of evident histologic or clinical proof, we do not consider silicone oil injection itself as having induced the mechanisms of sympathetic ophthalmia.