Abstract
Hoe 260 is a long-lasting and potent antisecretory and cytoprotective prostaglandin E2-analogue, having a favourable split between therapeutic gastric effects, effect on blood pressure and intestinal side effects; this compound could be a promising drug in ulcer therapy. (formula; see text)
MeSH terms
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Animals
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Blood Pressure / drug effects*
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Dinoprostone
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Dogs
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Gastric Acid / metabolism*
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Gastric Juice / drug effects
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Kinetics
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Male
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Prostaglandins E / pharmacology
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Prostaglandins E, Synthetic / pharmacology*
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Rats
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Rats, Inbred Strains
Substances
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Prostaglandins E
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Prostaglandins E, Synthetic
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HOE 260
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Dinoprostone