Gastrointestinal and cardiovascular effects of the prostaglandin analogue Hoe 260

Biomed Biochim Acta. 1984;43(8-9):S235-8.

Abstract

Hoe 260 is a long-lasting and potent antisecretory and cytoprotective prostaglandin E2-analogue, having a favourable split between therapeutic gastric effects, effect on blood pressure and intestinal side effects; this compound could be a promising drug in ulcer therapy. (formula; see text)

MeSH terms

  • Animals
  • Blood Pressure / drug effects*
  • Dinoprostone
  • Dogs
  • Gastric Acid / metabolism*
  • Gastric Juice / drug effects
  • Kinetics
  • Male
  • Prostaglandins E / pharmacology
  • Prostaglandins E, Synthetic / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Prostaglandins E
  • Prostaglandins E, Synthetic
  • HOE 260
  • Dinoprostone