[Toxicological characteristics of disodium salt of N-lauroyl-L-glutamic acid--a surface-active agent used in the food processing industry]

Vopr Pitan. 1984 Jul-Aug:(4):58-60.
[Article in Russian]

Abstract

To synthesize the disodium salt of N-lauroyl-L-glutamic acid (LG-Na2), use was made of the chloranhydride method with some modifications. The yield of the product was 85%. LG-Na2 possesses good surface-active properties and an emulsifying effect. The critical concentration of micelloformation of LG-Na2 is 6 10(-3) mol/l. LG-Na2 is a non-toxic compound. It is not cumulated in the animals' body. The LD50 for albino rats per os exceeds 10 000 mg/kg, that for mice 6500 mg/kg. It was shown in subacute experiments in rats that LG-Na2 did not produce any substantial influence on the animals' status or on some biochemical and morphological indicators of blood and organs. The authors suggest a tentative level of a safe oral action of LG-Na2 on man (10 mg per kg bw/day). LG-Na2 is likely to be widely used in food industry.

Publication types

  • English Abstract

MeSH terms

  • Adrenal Glands / metabolism
  • Alanine Transaminase / metabolism
  • Animals
  • Ascorbic Acid / metabolism
  • Aspartate Aminotransferases / metabolism
  • Cholinesterases / metabolism
  • Food Contamination / analysis*
  • Food-Processing Industry*
  • Hemoglobins / analysis
  • Lauric Acids / toxicity*
  • Liver / metabolism
  • Male
  • Mice
  • Organ Size / drug effects
  • Proteins / metabolism
  • Rats
  • Surface-Active Agents
  • Testis / metabolism

Substances

  • Hemoglobins
  • Lauric Acids
  • Proteins
  • Surface-Active Agents
  • lauric acid
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Cholinesterases
  • Ascorbic Acid