Acetylcoenzyme A and the synthesis of acetylcholine in neurones: review of recent progress

Gen Physiol Biophys. 1983 Aug;2(4):313-24.

Abstract

A review of recent progress in the investigation of the following two problems is given: (a) the origin of actyl groups in the acetylcoenzyme A which is used for the synthesis of actylcholine in mammalian nerve cells; (b) the role of acetylcoenzyme A in the control of acetylcholine synthesis. The data reviewed are mainly those that have been published after the reviews by Quastel (1978), Tucek (1978) and Jope (1979).

Publication types

  • Review

MeSH terms

  • ATP Citrate (pro-S)-Lyase / metabolism
  • Acetyl Coenzyme A / metabolism*
  • Acetylcholine / biosynthesis*
  • Animals
  • Choline O-Acetyltransferase / metabolism
  • Corpus Striatum / metabolism
  • Detergents / pharmacology
  • Glucose / metabolism
  • Humans
  • Mitochondria / metabolism
  • Nerve Endings / enzymology
  • Neurons / metabolism*
  • Synaptosomes / metabolism

Substances

  • Detergents
  • Acetyl Coenzyme A
  • Choline O-Acetyltransferase
  • ATP Citrate (pro-S)-Lyase
  • Glucose
  • Acetylcholine