Tryptophan excretion by a bradytroph of Hansenula polymorpha growing in methanol

Appl Environ Microbiol. 1978 Feb;35(2):459-61. doi: 10.1128/aem.35.2.459-461.1978.

Abstract

The growth of a bradytrophic mutant isolated from the methanol-utilizing yeast Hansenula polymorpha was found to be stimulated by both tyrosine and phenylalanine. The mutant contained about half as much chorismate mutase activity as the wild-type strain. When grown in a medium containing 2% mehtanol as the major carbon and energy source, the bradytroph excreted a low but significant level (28 mg/liter) of L-tryptophan.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Ascomycota / metabolism*
  • Chorismate Mutase / metabolism
  • Methanol / metabolism*
  • Mutation
  • Phenylalanine / pharmacology
  • Pichia / metabolism*
  • Tryptophan / biosynthesis*
  • Tyrosine / pharmacology

Substances

  • Tyrosine
  • Phenylalanine
  • Tryptophan
  • Chorismate Mutase
  • Methanol