Pharmacological properties of oxotremorine and its analogs

Life Sci. 1983 May 23;32(21):2401-13. doi: 10.1016/0024-3205(83)90365-x.

Abstract

The mechanism of action of oxotremorine is reviewed. A number of analogs of oxotremorine, including agonists, partial agonists and antagonists, are described. Many of these are potent and highly specific in their central actions. The possible basis for this specificity is outlined.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Binding, Competitive
  • Brain / drug effects
  • Brain / metabolism
  • Central Nervous System / drug effects
  • Chemical Phenomena
  • Chemistry
  • Ileum / metabolism
  • Oxotremorine / analogs & derivatives
  • Oxotremorine / antagonists & inhibitors
  • Oxotremorine / pharmacology*
  • Peripheral Nerves / drug effects
  • Receptors, Muscarinic / drug effects
  • Receptors, Muscarinic / metabolism
  • Structure-Activity Relationship

Substances

  • Receptors, Muscarinic
  • Oxotremorine
  • Acetylcholine