Defective parvoviruses acquired via the transplacental route protect mice against lethal adenovirus infection

Infect Immun. 1982 Jul;37(1):200-4. doi: 10.1128/iai.37.1.200-204.1982.

Abstract

Adeno-associated virus type 1 (AAV-1) interfered with the replication of its murine adenovirus (MAV) helper in primary mouse kidney cells and in 1-day-old ICR mice. Mice carrying AAV-1 acquired via the transplacental route were protected against lethal infection with MAV. The replication of AAV-1 in these mice could be triggered by multiple challenges with MAV, and antibodies to AAV-1 were subsequently detected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae / physiology*
  • Adenoviridae Infections / microbiology*
  • Animals
  • Animals, Newborn
  • Antibodies, Viral / analysis
  • Cells, Cultured
  • Dependovirus / immunology
  • Dependovirus / physiology*
  • Female
  • Haplorhini
  • Maternal-Fetal Exchange
  • Mice
  • Mice, Inbred ICR
  • Pregnancy
  • Viral Interference*

Substances

  • Antibodies, Viral