Chloroquine ototoxicity--a reversible phenomenon?

J Laryngol Otol. 1979 Aug;93(8):809-15. doi: 10.1017/s0022215100087740.

Abstract

The case of a six-year-old girl suffering from severe cochleo-vestibular dysfunction following a series of chloroquine phosphate injections is presented in this paper. Prompt institution of therapy with steroids and vaso-dilators has helped to restore the hearing to a serviceable (socially acceptable) level. A surmise is made about the pathogenesis of chloroquine ototoxicity and how prompt appropriate therapy may be able to reverse the process. A plea is made for early referral of these cases so that prompt attention may be paid to them.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Chloroquine / adverse effects*
  • Drug Combinations
  • Female
  • Hearing Loss, Sensorineural / chemically induced*
  • Hearing Loss, Sensorineural / drug therapy
  • Humans
  • Prednisolone / therapeutic use
  • Vitamin A / therapeutic use
  • Vitamin E / therapeutic use

Substances

  • Drug Combinations
  • Vitamin A
  • Vitamin E
  • Chloroquine
  • Prednisolone