Practical concepts of drug absorption, distribution and loss

C MacLeod; H Rabin; R Ogilvie; J Ruedy; M Caron; D Zarowny; R O Davies

Practical concepts of drug absorption, distribution and loss

Can Med Assoc J. 1974 Aug 17;111(4):341-6.

Authors

C MacLeod, H Rabin, R Ogilvie, J Ruedy, M Caron, D Zarowny, R O Davies

PMID: 4212256
PMCID: PMC1947703

Abstract

Serum concentrations of ampicillin were measured following administration of the drug orally and intravenously to nine normal volunteers. The results were analysed by graphic methods, and the effects of absorption, distribution and loss on the time serum concentration curve are discussed.

Publication types

Review

MeSH terms

Administration, Oral
Adult
Ampicillin / blood
Ampicillin / metabolism
Ampicillin / pharmacology
Bacillus subtilis / drug effects
Biological Assay
Dose-Response Relationship, Drug
Humans
Injections, Intravenous
Male
Methods
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / metabolism*
Time Factors

Substances

Pharmaceutical Preparations
Ampicillin