The aim of this study is to try to answer these two questions: is an intra-arterial chemotherapy of breast cancer technically possible? would such a treatment present a clinical interest? to this purpose, 12 tumoral breasts have been studied from a vascular, anatomic and arteriographic point of view; two of them were moreover subjected to scintigraphic and pathologic studies. The results seem to be encouraging, and studies are continued to specify different parameters of this therapeutic approach; then, the possibility of a clinical trial could be considered.