Translocation t(1;3)(p36;q21) in malignant myeloid stem cell disorders

Cancer Genet Cytogenet. 1986 May;22(1):75-81. doi: 10.1016/0165-4608(86)90140-8.

Abstract

A t(1;3)(p36;q21) translocation was found in bone marrow samples of two patients with hematologic disorders. One patient had a myelodysplastic syndrome evolving into acute nonlymphocytic leukemia (ANLL) M1 and the second patient had ANLL-M6 secondary to treatment for Hodgkin's disease. Because myelodysplastic syndromes and secondary leukemia are stem cell disorders, the t(1;3)(p36;q21) appears to be a chromosome abnormality in malignant myeloid stem cells.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Chromosome Banding
  • Chromosomes, Human, 1-3*
  • Female
  • Hodgkin Disease / therapy
  • Humans
  • Karyotyping
  • Leukemia / etiology
  • Leukemia / genetics*
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / complications
  • Myelodysplastic Syndromes / genetics*
  • Neoplasms, Multiple Primary / genetics
  • Translocation, Genetic*