Mean blood levels of eight components of clinical chemistry and the proportion of participants with abnormal chemistry values were calculated for persons with six dyslipoproteinemias (DLPs) and compared with findings from normolipidemic participants in 10 defined North American Lipid Research Clinics Program study populations. Most of the significant differences in mean chemistry levels were in persons with type IIB and IV DLP, and were characterized by higher mean levels of serum alkaline phosphatase, glucose, SGOT, and uric acid, and by lower mean levels of total bilirubin and thyroxine. Similarly, persons with type IIB and IV DLP were more likely to have significantly increased percentages of abnormal clinical chemistry values than were normolipidemics, but for a given chemistry this was rarely over 10% to 15% higher. With the exception of some participants with types IIB and IV DLP, the DLPs detected in these study populations were not associated with a substantial prevalence of abnormal clinical chemistry values and, by inference, were not frequently associated with the diseases or metabolic abnormalities for which these chemical abnormalities are indicators.