Research on traditional Chinese medicine as an effective drug for promoting wound healing

Tong Zhou; Chongyang Zhang; Xiao Wang; Jiazi Lin; Jiamin Yu; Yefang Liang; Huilin Guo; Mengru Yang; Xuejuan Shen; Jianhua Li; Ruixiang Shi; Yi Wang; Ji Yang; Zunpeng Shu

doi:10.1016/j.jep.2024.118358

Research on traditional Chinese medicine as an effective drug for promoting wound healing

J Ethnopharmacol. 2024 May 17:332:118358. doi: 10.1016/j.jep.2024.118358. Online ahead of print.

Authors

Tong Zhou¹, Chongyang Zhang¹, Xiao Wang¹, Jiazi Lin¹, Jiamin Yu¹, Yefang Liang¹, Huilin Guo¹, Mengru Yang¹, Xuejuan Shen¹, Jianhua Li¹, Ruixiang Shi¹, Yi Wang², Ji Yang³, Zunpeng Shu⁴

Affiliations

¹ School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, PR China.
² School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China. Electronic address: 784789997@qq.com.
³ School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China. Electronic address: yangji_email@163.com.
⁴ School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, PR China. Electronic address: shuzunpeng2010@163.com.

PMID: 38763370
DOI: 10.1016/j.jep.2024.118358

Abstract

Ethnopharmacological relevance: The incidence of skin trauma is high and the repair process is complex, often leading to poor healing and other issues, which can result in significant economic and social burdens. Traditional Chinese medicine (TCM) is a valuable resource with proven effectiveness and safety in wound repair, widely utilized in clinical practice. A systematic analysis of wound healing with a focus on TCM research progress holds both academic and clinical importance.

Aim of the review: This article reviews the research progress of TCM in promoting wound healing, and provides basic data for the development of innovative drugs that promote wound healing.

Materials and methods: This article provides a review of the literature from the past decade and conducts a thorough analysis of various databases that contain reports on the use of TCM for wound repair. The data for this systematic research was gathered from electronic databases including CNKI, SciFinder, and PubMed. The study explores and summarizes the research findings and patterns by creating relevant charts.

Results: This study reviewed the mechanism of wound healing, experimental TCM methods to promote wound healing, the theory and mode of action of TCM to promote wound healing, the active ingredients of TCM that promote wound healing, the efficacy of TCM formulae to promote wound healing, and the potential toxicity of TCM and its antidotes. This study enriched the theory of TCM in promoting wound healing.

Conclusion: Skin wound healing is a complex process that can be influenced by various internal and external factors. This article offers a theoretical foundation for exploring and utilizing TCM resources that enhance wound repair. By analyzing a range of TCM that promote wound healing, the article highlights the clinical importance and future potential of these medicines in promoting wound healing.

Keywords: Active ingredients; Mechanism; TCM formulae; Traditional Chinese medicine; Wound healing.

Publication types

Review