Bacteria-based cancer therapy: Looking forward

My-Van Tieu; Duc Trung Pham; Sungbo Cho

doi:10.1016/j.bbcan.2024.189112

Bacteria-based cancer therapy: Looking forward

Biochim Biophys Acta Rev Cancer. 2024 May 16:189112. doi: 10.1016/j.bbcan.2024.189112. Online ahead of print.

Authors

My-Van Tieu¹, Duc Trung Pham¹, Sungbo Cho²

Affiliations

¹ Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea.
² Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea; Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon 21999, Republic of Korea. Electronic address: sbcho@gachon.ac.kr.

PMID: 38761983
DOI: 10.1016/j.bbcan.2024.189112

Abstract

The field of bacteria-based cancer therapy, which focuses on the key role played by the prevalence of bacteria, specifically in tumors, in controlling potential targets for cancer therapy, has grown enormously over the past few decades. In this review, we discuss, for the first time, the global cancer situation and the timeline for using bacteria in cancer therapy. We also explore how interdisciplinary collaboration has contributed to the evolution of bacteria-based cancer therapies. Additionally, we address the challenges that need to be overcome for bacteria-based cancer therapy to be accepted in clinical trials and the latest advancements in the field. The groundbreaking technologies developed through bacteria-based cancer therapy have opened up new therapeutic strategies for a wide range of therapeutics in cancer.

Keywords: Bacteria cancer therapy; Biological engineering; Engineered bacteria; Wild-typed bacteria.

Publication types

Review