Combined or High Dose Immunosuppression in Inflammatory Bowel Disease patients who are NUDT15 Homozygous Harbors Risk of Developing Invasive Fungal Infections: A Case Series

David Mathew Thomas; Sandeep Kumar Mundhra; Shubham Prasad; Shekhar Swaroop; Umang Arora; Syed Ahmed; Ashu Seith Bhalla; Raju Sharma; Prasenjit Das; Saurabh Kedia; Vineet Ahuja

doi:10.1093/ibd/izae104

Combined or High Dose Immunosuppression in Inflammatory Bowel Disease patients who are NUDT15 Homozygous Harbors Risk of Developing Invasive Fungal Infections: A Case Series

Inflamm Bowel Dis. 2024 May 17:izae104. doi: 10.1093/ibd/izae104. Online ahead of print.

Affiliations

¹ Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India.
² Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, India.
³ Department of Pathology, All India Institute of Medical Sciences, New Delhi 110029, India.

PMID: 38757903
DOI: 10.1093/ibd/izae104

No abstract available

Plain language summary

NUDT15 homozygous mutations predispose patients to severe leucopenia, which invites risk of disseminated fungal infections when high doses or a combination of immunosuppressives are administered in this patient population.