The prognostic value of cancer stem cell markers in thyroid cancer: a systematic review

Xingqiao Peng; Peiye Zhu; Qiang Zhang; Jin Li

doi:10.5114/aoms/185169

The prognostic value of cancer stem cell markers in thyroid cancer: a systematic review

Arch Med Sci. 2024 Mar 11;20(2):686-690. doi: 10.5114/aoms/185169. eCollection 2024.

Authors

Xingqiao Peng¹, Peiye Zhu², Qiang Zhang^{1

2}, Jin Li¹

Affiliations

¹ Department of Oncology, Army Medical Center of PLA, Chongqing, China.
² College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China.

Abstract

Introduction: Thyroid cancer stem cells (TCSCs) play a crucial role in the pathogenesis, metastasis, and therapeutic response of thyroid cancer, making them promising biomarkers and potential targets for clinical intervention. This systematic review aims to qualitatively assess the impact of commonly used TCSC markers on the prognosis of thyroid cancer using qualitative methods.

Methods: In total, the analysis encompassed five articles.

Results: Six TCSC markers were involved, among which CD133, CD44, CD24, CD15 and ALDH1 were associated with the prognosis of thyroid cancer.

Conclusions: However, the utility of these TCSC markers in clinical practice for predicting the prognosis of thyroid cancer requires further research to provide additional evidence supporting their effectiveness.

Keywords: biomarker; cancer stem cells; meta-analysis; prognosis; thyroid cancer.