Effects of nonsynonymous single nucleotide polymorphisms of the KIAA1217, SNTA1 and LTBP1 genes on the growth traits of Ujumqin sheep

Zhichen Liu; Qing Qin; Chongyan Zhang; Xiaolong Xu; Dongliang Dai; Mingxi Lan; Yichuan Wang; Jingwen Zhang; Dan Zhao; Deqing Kong; Tian Qin; Danni Wu; Xuedan Gong; Xingyu Zhou; Alatan Suhe; Zhixin Wang; Zhihong Liu

doi:10.3389/fvets.2024.1382897

Effects of nonsynonymous single nucleotide polymorphisms of the KIAA1217, SNTA1 and LTBP1 genes on the growth traits of Ujumqin sheep

Front Vet Sci. 2024 May 2:11:1382897. doi: 10.3389/fvets.2024.1382897. eCollection 2024.

Authors

Zhichen Liu¹, Qing Qin¹, Chongyan Zhang¹, Xiaolong Xu¹, Dongliang Dai¹, Mingxi Lan¹, Yichuan Wang¹, Jingwen Zhang¹, Dan Zhao¹, Deqing Kong¹, Tian Qin¹, Danni Wu¹, Xuedan Gong¹, Xingyu Zhou¹, Alatan Suhe², Zhixin Wang^{1

3

4

5}, Zhihong Liu^{1

3

4

5}

Affiliations

¹ College of Animal Science, Inner Mongolia Agricultural University, Hohhot, China.
² East Ujumqin Banner Hersig Animal Husbandry Development Limited Liability Company, Xilin Gol League, Xilinhot, China.
³ Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot, China.
⁴ Key Laboratory of Mutton Sheep Genetics and Breeding, Ministry of Agriculture, Hohhot, China.
⁵ Goat Genetics and Breeding Engineering Technology Research Center, Hohhot, China.

Abstract

Sheep body size can directly reflect the growth rates and fattening rates of sheep and is also an important index for measuring the growth performance of meat sheep. In this study, high-resolution resequencing data from four sheep breeds (Dorper sheep, Suffolk sheep, Ouessant sheep, and Shetland sheep) were analyzed. The nonsynonymous single nucleotide polymorphisms of three candidate genes (KIAA1217, SNTA1, and LTBP1) were also genotyped in 642 healthy Ujumqin sheep using MALDI-TOFMS and the genotyping results were associated with growth traits. The results showed that different genotypes of the KIAA1217 g.24429511T>C locus had significant effects on the chest circumferences of Ujumqin sheep. The SNTA1 g.62222626C>A locus had different effects on the chest depths, shoulder widths and rump widths of Ujumqin sheep. This study showed that these two sites can be used for marker-assisted selection, which will be beneficial for future precision molecular breeding.

Keywords: KIAA1217; LTBP1; SNTA1; Ujumqin sheep; nsSNP.

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Project of Northern Agriculture and Livestock Husbandry Technical Innovation Center, Chinese Academy of Agricultural Sciences (BFGJ2022002); The National Key R&D Program of China (2021YFD1200901); National Natural Science Foundation of China (32060742); The Major Science and Technology Projects of Inner Mongolia Autonomous Region (2020ZD0004); The central government guides local science and technology development funds (2022ZY0185); Higher educational Basic scientific research business fee project of Inner Mongolia Autonomous Region (BR221005); and University Youth Science and Technology Talent Support Project of Inner Mongolia Autonomous Region (NJYT23012).