The genetics and clinical outcomes in 151 cases of fetal growth restriction: A Chinese single-center study

Can Peng; LanPing Hu; XiuFen Bu; HongYu Li; XuanYu Jiang; ShiHao Zhou; Li Deng; Jun He; SiYuan LinPeng

doi:10.1016/j.ejogrb.2024.05.004

The genetics and clinical outcomes in 151 cases of fetal growth restriction: A Chinese single-center study

Eur J Obstet Gynecol Reprod Biol. 2024 May 11:298:128-134. doi: 10.1016/j.ejogrb.2024.05.004. Online ahead of print.

Authors

Can Peng¹, LanPing Hu¹, XiuFen Bu¹, HongYu Li¹, XuanYu Jiang¹, ShiHao Zhou¹, Li Deng¹, Jun He², SiYuan LinPeng³

Affiliations

¹ Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, Hunan 410007, China.
² Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, Hunan 410007, China. Electronic address: 19252702@qq.com.
³ Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, Hunan 410007, China. Electronic address: linpengsiyuan@163.com.

PMID: 38756052
DOI: 10.1016/j.ejogrb.2024.05.004

Abstract

To determine the detection rate of chromosomal abnormalities and pregnancy outcomes in fetuses with intrauterine growth restriction. Study design A total of 151 fetal samples with intrauterine growth restriction were divided into the isolated fetal growth restriction (FGR) group, FGR group with structural malformation, and FGR group with non-structural malformation, according to ultrasound abnormalities. The enrolled patients were divided into an early onset FGR group (<32 weeks) and a late-onset FGR group (≥32 weeks). Chromosomal karyotype and microarray analyses were performed and pregnancy outcomes were monitored. Results The karyotypes of 122 patients were analyzed. Four patients exhibited abnormal chromosome numbers or structures. Variations in copy number were detected in 151 cases; 19 cases were found to have chromosomal abnormalities, with a positivity rate of 12.6 %. There was one trisomy in 18 cases, one trisomy in 21 cases, eight pathogenic copy number variations (CNVs), and nine CNVs of unknown clinical significance. The detection rate of FGR combined with structural malformation was significantly higher than that of isolated FGR group. The detection rate of FGR with structural malformations was significantly higher than that with non-structural malformations. The positive detection rate in the FGR group was similar to that in the FGR group with non-structural malformations, with no statistical significance. Chromosomal abnormalities were detected in 17 patients with early onset FGR, with a positivity rate of 13.8 %. Two cases of chromosomal abnormalities were detected in the late-onset FGR group, with a positive rate of 7.1 %, with no statistical significance. A total of 151 fetuses with FGR were followed up for pregnancy outcomes, resulting in 36 cases of pregnancy termination and 13 cases of loss to follow-up. Among the 102 delivered fetuses, six exhibited delayed growth and development, one presented with hypospadias, and another failed the hearing screening. The remaining 94 fetuses demonstrated normal growth and development. Conclusions This study confirms the value of CNV detection in fetuses and dynamic ultrasound monitoring for fetuses with intrauterine growth restriction.

Keywords: Chromosomal karyotype; Chromosomal microarray analysis; Fetal growth restriction; Pregnancy outcomes.