Purpose: This study aims to characterize the relationship between ablation zone volume (AZV) and microwave ablation (MWA) energy in an in vivo porcine liver model following arterial embolization.
Materials and methods: With animal IRB approval, eleven female swine underwent either right (n= 5) or left (n= 6) hepatic artery embolization under fluoroscopic guidance. Subsequently, ultrasound guided MWA was performed in each liver segment (left lateral, left medial, right medial, right lateral) at either 30 Watts (W) (n=4 lobes), 60W (n=4), 65W (n=20), 90W (n=8), 120W (n=4), or 140W (n=4) continuously for 5 minutes. Post-procedural volumetric segmentation was performed on standardized multiphase T1 MRI sequences.
Results: AZVs in embolized lobes (15.8 ± 10.6 mL) were significantly larger than non-embolized lobes (11.2 ± 6.5 mL, P <0.01). MWA energy demonstrated significant positive linear correlation with both embolized (R2=0.66, P <0.01) and non-embolized lobes (R2=0.64, P < 0.01). The slope of the linear models corresponded to a 0.95 ± 0.16 and 0.54 ± 0.09 mL/kJ increase in ablation volume per applied kJ of energy (E) in embolized and non-embolized lobes, respectively. In the multivariate model, embolization status significantly modified the relationship between E and AZV as described by the interaction term: 0.42*E*(Embolization Status), (P = 0.031).
Conclusion: Linear models demonstrate a near 1.8 fold increase in ratio of AZV per unit E, R(AZV:E), when applied to embolized lobes relative to non-embolized lobes. Absolute AZV differences between embolized and non-embolized lobes were greater at higher power MWA.
Keywords: ablation zone volume to energy ratio; combination therapy; microwave ablation.
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