Efficiency of therapeutic plasma exchange in critically ill systemic rheumatologic diseases: A single-center 9-year experience

Jing Guo; Xiaolong Huang; Jianhua Li; Xiaorong Zhang; Ping Zhong; Guiyang Lu; Xinxin Wang; Weiyuan Luo; Yaogui Ning

doi:10.1111/1744-9987.14144

Efficiency of therapeutic plasma exchange in critically ill systemic rheumatologic diseases: A single-center 9-year experience

Ther Apher Dial. 2024 May 15. doi: 10.1111/1744-9987.14144. Online ahead of print.

Authors

Jing Guo^{1

2

3}, Xiaolong Huang^{1

2

3}, Jianhua Li^{1

2

3}, Xiaorong Zhang^{1

2

3}, Ping Zhong⁴, Guiyang Lu^{1

2

3}, Xinxin Wang^{1

2

3}, Weiyuan Luo^{1

2

3}, Yaogui Ning^{1

2

3}

Affiliations

¹ Department of Intensive Care Unit, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
² School of Medicine, Xiamen University, Xiamen, Fujian, China.
³ The School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China.
⁴ BE and Phase I Clinical Trial Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.

PMID: 38751182
DOI: 10.1111/1744-9987.14144

Abstract

Introduction: Therapeutic plasma exchange (TPE), an effective method to eliminate harmful soluble mediators associated with tissue injury, serves as a crucial intervention for systemic rheumatologic diseases (SRDs). However, its value in critically ill SRDs remains uncertain. This retrospective study aims to evaluate the efficacy of TPE in SRDs.

Methods: Critically ill SRD patients admitted to the department of intensive care unit of a large tertiary hospital receiving TPE from January 2011 to December 2019 were included.

Results: A total of 91 critically ill SRD patients received TPE were enrolled. Their mean age was 47.67 ± 16.35 years with a female predominance (n = 68). Significant decrease in SOFA score post-TPE treatment was observed (p < 0.05). There were no TPE-related fatalities. Improvement was observed in 64 (70.32%) patients.

Conclusion: This study shows favorable clinical outcomes. TPE may be an acceptable treatment option for critically ill SRD patients.

Keywords: critically ill patients; systemic rheumatologic diseases; therapeutic plasma exchange.