The role of Interleukin-22 in severe acute pancreatitis

Hongli Yang; Ruofan Cao; Feifei Zhou; Ben Wang; Qianqian Xu; Rui Li; ChunHua Zhang; Hongwei Xu

doi:10.1186/s10020-024-00826-7

The role of Interleukin-22 in severe acute pancreatitis

Mol Med. 2024 May 15;30(1):60. doi: 10.1186/s10020-024-00826-7.

Authors

Hongli Yang^#^{1

2}, Ruofan Cao^#^{1

2}, Feifei Zhou¹, Ben Wang¹, Qianqian Xu³, Rui Li^{1

2}, ChunHua Zhang^#⁴, Hongwei Xu^#^{5

6}

Affiliations

¹ Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, 250021, P.R. China.
² Medical Science and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, P.R. China.
³ Department of Gastroenterology, Cheeloo College of Medicine, Shandong Provincial Hospital, Shandong University, Ji'nan, Shandong, 250021, P.R. China.
⁴ Shandong First Medical University, Ji'nan, Shandong, 250117, P.R. China.
⁵ Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, 250021, P.R. China. xuhongwei@sdfmu.edu.cn.
⁶ Medical Science and Technology Innovation Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250021, P.R. China. xuhongwei@sdfmu.edu.cn.

^# Contributed equally.

Abstract

Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mortality and a bleak prognosis. Interleukin-22 (IL-22) is a cytokine that may have a significant role in SAP. IL-22, a member of the IL-10 cytokine family, has garnered growing interest owing to its potential tissue-protective properties. Recently, emerging research has revealed its specific effects on pancreatic diseases, particularly SAP. This paper provides a review of the latest knowledge on the role of IL-22 and its viability as a therapeutic target in SAP.

Keywords: Autophagy; IL -22; Inflammation; SAP-induced multiorgan injury; Sever acute pancreatitis.

Publication types

Review

MeSH terms

Acute Disease
Animals
Humans
Interleukin-22*
Interleukins* / metabolism
Pancreatitis* / immunology
Pancreatitis* / metabolism

Grants and funding

No. 82170650/Innovative Research Group Project of the National Natural Science Foundation of China