A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

Yuta Awano; Ryoya Ishii; Yume Takahashi; Hayama Tsutsumi; Yoshihiro Watanabe; Masaaki Sonoda; Rei Hokari; Masato Iwatsuki; Yuki Inahashi

doi:10.1038/s41429-024-00737-z

A new polyene macrolide antibiotic, machidamycin, produced by Streptomyces sp. K22-0017

J Antibiot (Tokyo). 2024 May 15. doi: 10.1038/s41429-024-00737-z. Online ahead of print.

Authors

Yuta Awano¹, Ryoya Ishii², Yume Takahashi¹, Hayama Tsutsumi^{1

3}, Yoshihiro Watanabe^{1

3}, Masaaki Sonoda¹, Rei Hokari^{1

3}, Masato Iwatsuki^{1

3}, Yuki Inahashi^{4

5}

Affiliations

¹ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
² School of Science, Kitasato University, 1-15-1 Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
³ Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
⁴ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. y-ina@lisci.kitasato-u.ac.jp.
⁵ Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. y-ina@lisci.kitasato-u.ac.jp.

PMID: 38750248
DOI: 10.1038/s41429-024-00737-z

Abstract

A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.

Abstract

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