Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

Min-Shan Li; Xiang-Hong Wang; Heng Wang

doi:10.1007/s11596-024-2872-4

Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation

Curr Med Sci. 2024 May 15. doi: 10.1007/s11596-024-2872-4. Online ahead of print.

Authors

Min-Shan Li^{1

2

3}, Xiang-Hong Wang^{1

2

3}, Heng Wang^{4

5

6}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
² Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
³ Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, 430030, China.
⁴ Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. martin_wangheng@hotmail.com.
⁵ Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. martin_wangheng@hotmail.com.
⁶ Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, 430030, China. martin_wangheng@hotmail.com.

PMID: 38748372
DOI: 10.1007/s11596-024-2872-4

Abstract

Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These receptors have been found to modulate the immune system in several inflammatory diseases, including inflammatory bowel disease, atopic dermatitis, and asthma. Proton-activated GPCRs belong to the G protein-coupled receptor family and can detect alternations in extracellular pH. This detection triggers downstream signaling pathways within the cells, ultimately influencing the function of immune cells. In this review, we specifically focused on investigating the immune response of proton-activated GPCRs under inflammatory conditions.

Keywords: disease; immunomodulation; inflammation; proton-activated G protein-coupled receptors.

Publication types

Review