In typical multiple-input multiple-output (MIMO) optical camera communication (OCC) systems, the spatial correlation of MIMO channels is large. Optical signals between light sources can easily interfere with each other, negatively impacting the overall transmission performance. In this work, we propose a time-multiplexing integral modulation scheme for a non-line-of-sight MIMO OCC system, where each LED transmits different signals to improve both the data rate and security of the system. A genetic algorithm (GA)-based adaptive multi-threshold scheme is designed to demodulate the blurred fringes in multi-level pulse amplitude modulation. The experimental results show that at a distance of 2.5 m, a data rate of 16.4 kb/s can reach with the BER performance of 3.01 × 10-3, which validates the superiority and reliability of our proposed schemes.